Technology

Alzheimer's disrupts circadian rhythms of plaque-clearing brain cells

Source

Hacker News

Published

Oct 26, 2025

TL;DR

AI Generated

Alzheimer's disease disrupts the circadian rhythms of brain cells involved in clearing amyloid plaques, as shown in a study by researchers at WashU Medicine. The study, published in Nature Neuroscience, found that the daily rhythms of genes in microglia and astrocytes were altered in mice with amyloid accumulations, impacting key brain functions. These findings suggest that targeting circadian rhythms in these brain cells could potentially be a way to treat Alzheimer's disease by preventing amyloid accumulation. Understanding and manipulating the circadian system may offer insights into optimizing brain function and combating the progression of the disease.

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Lead Limited Brain and Language Development in Neanderthals and Other Hominids?

A UC San Diego engineer has received a grant to study aging in brain and heart cells. The research aims to explore how aging affects these cells and potentially lead to new insights into age-related conditions. The grant will support investigations into the impact of aging on brain and heart health, with potential implications for understanding diseases like Alzheimer's and heart disease. This study could provide valuable information on how aging impacts different organs and systems in the body.

Hacker News•

7 months ago

MIT Technology Review

The Download: our bodies’ memories, and Traton’s electric trucks

The article discusses how our bodies remember movements and exercise, with muscles themselves having memory. Traton, a subsidiary of Volkswagen, is producing zero-emission electric trucks to reduce carbon emissions in the transportation sector. A new test is being developed to measure immune health, providing a score to assess immune system status. The piece also highlights China's crackdown on Nvidia's China-specific chips and Tesla's 'full self-driving' feature under investigation.

MIT Technology Review•

7 months ago

Dr. L.C. Lu on TSMC Advanced Technology Design Solutions

Dr. L.C. Lu, a key figure at TSMC, focuses on design-technology co-optimization, packaging innovations, and AI-driven methodologies for next-gen semiconductor systems. TSMC emphasizes DTCO and DDCL innovations for scaling from N5 to A14 nodes, with NanoFlex and NanoFlex Pro architectures offering efficiency gains. N2P and N2U nodes incorporate advanced DTCO and power delivery optimizations, with hybrid dual-rail architectures achieving significant energy savings. TSMC collaborates with EDA partners for AI integration, enhancing productivity and design quality. Advanced packaging technologies like CoWoS and SoIC play a crucial role in enabling AI scaling, with memory bandwidth and interconnect performance scaling aggressively. TSMC addresses power delivery and thermal management challenges in AI systems through advanced solutions. TSMC's advancements in design methodologies and AI-driven automation promise improved productivity and scalability in chip-package co-design.

SemiWiki•

3 hours ago

MindsEye's sabotage mission is being slammed as dull and pointless

Build A Rocket Boy accuses individuals of sabotaging MindsEye's launch, spending over €1 million on damaging efforts. The studio integrates the controversy into a new in-game mission, Blacklist, to showcase evidence of sabotage to players. However, reports describe the mission as lackluster and failing to deliver a compelling narrative. Critics attribute the launch issues to internal problems, such as management and design decisions, casting doubt on the sabotage claims. The saga continues as MindsEye's post-launch turmoil unfolds.

TweakTown•

4 hours ago